ISIS Elixir for Life Full Fat Colostrum
                                                                                           

Description and Suggested Applications

EFL_APS-18F is a pasteurized, 100% full fat colostrum powder produced from raw colostrum collected only from
milkings within 16 hours after birth.  EFL_APS-18F is processed both at low pressures and temperatures and is
spray dried using indirect steam to maintain maximum bio-activity.  The colostrum used to produce EFL_APS-18F
is from antibiotic and pesticide free sources.  

Suggested applications include: immune system enhancement, nutritional supplement, digestive health
improvement, protein supplement and alternative treatment for general health.

Major Active Component Analysis

                                                      Specification                    Typical                       Method                

Protein % (Nx6.38) db                               45.0 min                       50.0                        Kheldal
Total Immunoglobulins %                          18.0 min                       22.0                        HPLC (dry basis)
Immunoglobulins (Type G1 & G2) %         15.0 min                       18.0                        HPLC (dry basis)
Immunoglobulins (Type A) %                      2.0 min                        2.60                       HPLC (dry basis)
Immunoglobulins (Type M) %                    0.75 min                        1.40                      HPLC (dry basis)
Immunoglobulins (Type D) %                    0.15 min                        0.20                      HPLC (dry basis)
Immunoglobulins (Type E) %                    0.10 min                        0.15                       HPLC (dry basis)
Lactoferrin %                                              0.5 min                        0.75                       HPLC (dry basis)
Transferrin (mg/g)                                      3.0 min                         4.50                      HPLC (dry basis)
Lactoperoxidase-thiocyanate %                 0.3 min                        0.45                       HPLC (dry basis)
Proline-Rich Polypeptides (PRPs) %          3.0 min                        4.0                         HPLC (dry basis)
Insulin Growth Factor (Type 1) µg/g           1.0 min                        2.3                         ELISA (dry basis)
Insulin Growth Factor (Type 2) ng/g           100 min                        140                        ELISA (dry basis)
Derived Platelet Growth Factor ng/g           3.5 min                        4.2                         HPLC (dry basis)
Epidermal Growth Factor µg/g                     0.8 min                        1.1                         ELISA (dry basis)
Fibroblast Platelet Growth Factor ng/g        4.0 min                        5.0                         ELISA (dry basis)
Transforming Growth Factor Alpha ng/g     15.0 min                      22.0                        ELISA (dry basis)
Transforming Growth Factor Beta mg/g       0.15 min                       0.21                      ELISA (dry basis)
Nerve Growth Factor ng/g                            8.0 min                       11.0                        ELISA (dry basis)
Leptin ng/g                                                 35.0 min                       50.0                        ELISA (dry basis)

Vitamin Analysis*

Vitamin B6 µg/g                                         10.0 min                        15.0                     Mass spec. (wet basis)
Vitamin B12 µg/g                                      0.10 min                         0.16                     Mass spec. (wet basis)
Vitamin E µg/g                                          0.15 min                         0.20                     Mass spec. (wet basis)
Vitamin A µg/g                                          15.0 min                        20.0                      Mass spec. (wet basis)
Vitamin C µg/g                                          0.25 min                         0.40                     Mass spec. (wet basis)
Vitamin D µg/g                                          1.00 min                         1.20                     Mass spec. (wet basis)
Thiamin (Vitamin B1)µg/g                        100.0 min                        150                     Mass spec. (wet basis)
Folic Acid µg/g                                            2.0 min                         2.3                      Mass spec. (wet basis)
Pantothenic Acid µg/g                                 2.0 min                         2.3                      Mass spec. (wet basis)
Riboflavin (Vitamin B2) µg/g                      50.0 min                         60.0                    Mass spec. (wet basis)
Beta-carotene µg/g                                   180 min                          220                     Mass spec. (wet basis)
Glycoconjugates µg/g                                2.0 min                           2.4                     Mass spec. (wet basis)
Glycogen µg/g                                         40.0 min                          56.0                     Mass spec. (wet basis)
Retinoic Acid µg/g                                      5.0 min                           8.0                     Mass spec. (wet basis)

                                 

Analytical and Microbiological Analysis*
                                                       Specification              Typical                     Method                      
      Moisture %                                      5.0 max                 4.50                         CEM
      Protein % (Nx6.38) db                   45.0 min                50.0                           Kheldal
      Ash %                                             9.0 max                  7.0                Mass Spec.
      Fat %                                            24.0 max                22.0                Mojonnier
      Lactose %                                    20.0 max.                16.5                by difference
      Sediment                                             B                        A                    Pad
      pH                                                  6.5 < 7.5                 7.0                10% sol., 20C
      Bulk density                                 0.25 < 0.35               0.30                grams / cc
      Standard Plate Count (col/g)     50,000 max               5,000                Standard**
      Yeast and Mold (col/g)                  10 max                    <10                 Standard**
      Coliform (col/g)                              10 max.                   <10                3M Petrifilm
      E.Coli (col/g)                                  10 max.                     <1                3M Petrifilm
      Salmonella sp.                            Neg. / 25g                 Neg.                ELISA
      Listeria sp.                                 Neg. / 25g                  Neg.                ELISA

Essential Amino Acid Analysis* (weight/weight basis)(GC/MS)   Non Essential Amino Acid Analysis*(w/w) (GC/MS)

Isoleucine                                1.46%                                              Arginine                2.30%
Leucine                                     2.37%                                            Cystine                  1.12%
Histidine                                   1.46%                                              Glutanic Acid        9.13%
Methionine                               4.08%                                              Alanine                 2.50%
Lysine                                      4.18%                                              Tyrosine                4.96%
Threonine                                4.03%                                              Glycine                  1.77%
Phenylalanine                          2.42%                                              Proline                   5.12%
Valine                                      2.16%                                              Aspartic Acid          5.57%
Tryptophan                              1.17%                                              Serine                    4.77%
                  
Other Minor Components not Quantified
Beta 2- microglobulin, Enzymes, Haemopexin, Haptoglobulin, Orotic Acid, Peroxidase, Xanthine Oxidase Enzyme,
Gonadotropin-Releasing Hormone (GnRH), Prolactin, Insulin, Sulfur, Glycoproteins: - (Including Protease and
Trypsin Inhibitors), Lactalbumin, Multimeric a-Lactalbumin, Cytokines, Lysozymes, Gamma Globulin, B
Lactoglobulin, Complement 3 & 4 (C3 & C4), Kappa Casein, Alpha 2-AP glycoprotein, Alpha 1- antitrypsin, Alpha
2- macroglobulin, Orosomucoids, Prealbumin, Albumin, Oligosaccharides, Non Specific Inhibitors (NSI’s),
Secretory IgA (SigA), IgA Specific Helper

Mineral Analysis* and Physical Properties
  mg/100gm           Specification       Typical          Heavy Metals              Properties
   Sodium               150 < 300              200              Lead    <1ppm           Solubility:          Good
   Calcium              150 < 400              250              Mercury   <1ppm        Flavor:          Clean & Bland
   Potassium          150 < 400              250              Arsenic    <1ppm        Odor:                Clean
   Magnesium         250 <500              400                                                 Appearance: Free flowing    
   Chromium            30 < 60                  40                                                                       & non-caking
   Zinc                     30 < 60                   40                           
   Chloride                 < 100                   40                                                     

Packaging, Shipping and Storage

Colostrum proteins are hygroscopic and can absorb odors.  Temperatures below 75 degrees F, relative humidity
below 65% and an odor free environment will extend storage life.  Stocks should be used in rotation and
preferably within three years.    

* Where not specified results are reported on “ as is” basis except.    ** Standard Methods for Examination of
Dairy Products, 16th Edition      


    Manufactured for ISIS Nutraceuticalsby APS™, LLC